Escherichia coli Nissle 1917 (EcN) is one of the extensively characterized probiotic strains owing to its beneficial traits like (1) production of antimicrobials such as microcin and bacteriocin, (2) modulation of host immune responses, and (3) competitive elimination of pathogens residing in the intestine [23,24,25,26,27,28,29,30,31]. The
The probiotic Escherichia coli strain Nissle 1917 (DSM 6601, Mutaflor), generally considered beneficial and safe, has been used for a century to treat various intestinal diseases. However, Nissle 1917 hosts in its genome the pks pathogenicity island that codes for the biosynthesis of the genotoxin colibactin.
Escherichia coli Nissle 1917 (EcN, Mutaflor) is a Gram-negative bacterium widely used as a probiotic strain. Its probiotic potential includes prevention of pathogenic invasion, positive effect on epithelial cells, host smooth muscle cell activity, and host immune response ( Reissbrodt et al., 2009 , Bär et al., 2009 , Kamada et al., 2008 ).
To achieve colon tissue targeting effects, the HPN nanoparticles were conjugated to the surface of modified probiotic Escherichia coli Nissle 1917 (EcN). To enhance the bacteriotherapy of EcN, we encapsulated EcN cells with a poly-norepinephrine (NE) layer that can protect EcN against environmental assaults to improve the viability of EcN in
Here, properties of that E. coli Nissle 1917 strain are compared with other commercially available E. coli probiotic strains, with emphasis on their human applications. A literature search formed the basis of a summary of research findings reported for the probiotics Mutaflor, Symbioflor 2, and Colinfant.
Probiotic microorganisms are defined as viable nutritional agents conferring benefit to the health of the human host. Especially, Escherichia coli strain Nissle 1917 (EcN) was shown to be equally effective as mesalazine in the maintenance of remission in ulcerative colitis (UC). Presumably, the ther …
First World War. For more than 100 years, doctors have used a “friendly” E. coli strain called Nissle to prevent and treat infectious diarrhea. Alfred Nissle, a German physician and researcher
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e coli nissle 1917 probiotic
